Current study on nutrition-based interventions in prostate cancer

Current study on nutrition-based interventions in prostate cancer

The results of a recent nutritional intervention study have been published in the journal European Urology Oncology . This international, randomized, double-blind, placebo-controlled study, led by Prof. Thomas and his research team, represents one of the most comprehensive investigations to date into nutrition-based strategies in men with low-risk, but progressive, prostate cancer.

Study design

In this clinical study, men with early but progressive prostate cancer received a targeted nutritional intervention before considering invasive measures such as surgery, radiation therapy, or hormone therapy.

Participants either:

• a phytochemical-rich dietary supplement (YourPhyto)

• a probiotic (YourgutPlus)

• a combination of both preparations

• or a placebo.

None of the study participants were taking any other dietary supplements related to prostate cancer at the same time.

Key findings of the study

The following effects were observed in the combined intervention group:

• PSA progression slowed by 44%

• MRI scans show stabilization of the disease in 84% of cases.

• Lesion reduction in 7% of participants

• Improvement of urinary tract symptoms by 25%

• Improvement in erectile function by 11%

• Reduction of systemic inflammatory markers

• Improved grip strength as a marker of physical performance

According to the authors, this study is the first randomized controlled trial to clinically evaluate a combined phytochemical and probiotic intervention in this context.

Composition of the interventions studied

Phytochemical-rich combination

The tested plant-rich formulation contained, among other things:

• pomegranate

• broccoli

• Green tea

• turmeric

• Cranberry

• Organic ginger

The manufacturing process included standardized extraction, purification, and dosing of active plant substances to ensure reproducible quality.

Probiotic combination

The probiotic used contained:

• 5 Lactobacillus strains

• Inulin from chicory

• Vitamin D

Previous studies have investigated the effects of this probiotic combination, including in relation to immune function and vitamin D status.

Scientific background

Previous laboratory and observational studies suggest that:

• Secondary plant compounds may possess inflammation-modulating properties

• The gut microbiome plays a role in systemic inflammatory processes.

• A combination of a diet rich in phytochemicals and probiotics could have synergistic effects.

However, prior to conducting this study, no clinical data on the combined use in this patient group were available.

Grip strength and systemic markers

Grip strength is considered a practical biomarker for physical performance and functional age. In this study, a statistically significant improvement was observed in the intervention group.

Safety and quality standards

Since the intervention was carried out within the framework of national medical studies, manufacturing and quality control were subject to strict ethical and regulatory requirements.

Classification

The authors conclude that a targeted combination of a phytochemical-rich diet and probiotic supplementation in men with low-risk, progressive prostate cancer was associated with measurable changes in certain clinical markers.

Further studies are planned to confirm these results and to better understand the long-term significance of the intervention.

Sources

Thomas RJ et al. Increasing Phytochemical-rich Foods and Lactobacillus Probiotics in Men with Low-risk Prostate Cancer – A Randomized, Double-blind, Placebo-controlled Trial. European Urology Oncology , 2025.

PMID: 41152052